moxidectin side effects

Protect from light. • Loiasis: Pretreatment assessment for loiasis is recommended in any patient with exposure to Loa loa-endemic areas; serious, sometimes fatal, encephalopathy may occur following treatment with moxidectin in onchocerciasis patients with concomitant loiasis. Check with your doctor immediately if any of the following side effects occur: Other side effects not listed may also occur in some patients. Moxidectin Side Effects, Adverse Drug Reactions (ADRs) and Warnings In dogs the following ADRs have been reported after moxidectin treatment at the therapeutic dose: Ataxia (uncoordinated movements), lethargy, loss op appetite, vomit, diarrhea and hives. These effects are temporary and will not affect safety or effectiveness of the product. Social media is buzzing about an Australian study on the possible antiviral effects that ivermectin might have on the COVID-19 virus. Females of reproductive potential were required to use long acting contraception during clinical studies (Awadzi 2014; Korth-Bradley 2011) likely due to the long terminal half-life of moxidectin. Studies 2 and 3: no effects were identified in reproductive indices (females) or semen quality characteristics (males). Moxidectin, an anthelminthic agent, is active against the microfilariae of O. volvulus, but not effective in killing the adult worms. These side-effects are possible, but do not always occur. Safety and efficacy of repeat administration of moxidectin in patients with O. volvulus has not been studied. Moxidectin Tablets are available as white to pale yellow uncoated oval-shaped tablets, debossed on one side with “AKKA”. Adverse events were observed in some animal reproduction studies. • Mazzoti reaction: Moxidectin treatment may cause cutaneous, ophthalmological, and/or systemic reactions (Mazzoti reaction) of varying severity, due to allergic and inflammatory host responses to the death of microfilariae. All patients have their different intensity of side effects. SIDE EFFECTS Side effects have not been reported for dogs using the topical product as directed. Zoetis knows moxidectin can be harmful to dogs. Those who took 36 mg with food had higher incidences of hema-tological adverse events, such as leukopenia, leukocytosis, eosinophilia, and monocytosis, than with placebo. Adverse effects. Consult your doctor if you observe any of the following side-effects, especially if they do not go away. We comply with the HONcode standard for trustworthy health information -. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Moxidectin - General Description: Moxidectin is an injectable parasiticde given at the veterinary clinic to dogs 6 months of age and older to prevent heartworm disease. Available for Android and iOS devices. Drugs may be approved days, weeks, or months before they’re launched, so we encourage you to check back. These are not all of the side effects that may occur. There is a trend toward an increased incidence of these adverse reactions in patients with higher microfilarial burden. Vaccine updates, safe care and visitor guidelines, and trusted coronavirus information, Mayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic School of Continuous Professional Development, Mayo Clinic School of Graduate Medical Education, FREE book offer – Mayo Clinic Health Letter, New Year Special -  40% off – Mayo Clinic Diet Online, bloating or swelling of the face, arms, hands, lower legs, or feet, dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position, fast, pounding, or irregular heartbeat or pulse, sores, ulcers, or white spots on the lips or in the mouth, burning, dry, itching, or watering of the eyes, redness, pain, or swelling of the eye, eyelid, or inner lining of the eyelid. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Talk to your doctor if you have questions. Due to its bitter taste, this drug may cause temporary profuse drooling if ingested. Only the healthcare provider has the knowledge and training to decide which medicines are right for a specific patient. 5.1 Cutaneous, Ophthalmological and/or Systemic Adverse Reactions Treatment with Moxidectin Tablets may cause cutaneous, ophthalmological and/or systemic reactions of varying severity (Mazzotti reaction). If you notice any other effects, check with your healthcare professional. Cough. If you notice any of these side effects or have any concerns about your dog, please contact your veterinarian as soon as possible. The higher the quantity taken by an individual, the greater the healing effect and the corresponding side effect. Pharmacokinetics were dose-proportional and there was little or no systemic accumulation. The following adverse drug reactions and incidences are derived from product labeling unless otherwise specified. Moxidectin’s chemical formulation is slightly different to Ivermectin, well known here as a horse and livestock deworming remedy. Consumer Information Use and Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away: Stomach pain. All rights reserved. Oral: Administer without regard to meals. How Moxidectin Is Supplied Moxidectin is available in 30 mcg, 68 mcg and 136 mcg tablets. Drug information provided by: IBM Micromedex. Side effects increased as the dose was raised, so there is no sense in going crazy and using a higher dose. These reactions generally occur and resolve in the first week post-treatment. Ensure you consult your health care provider immediately you notice an unusual side effect affect the consumption of Moxidectin. side effects or only have minor side effects. All drugs may cause side effects. This site complies with the HONcode standard for trustworthy health information: verify here. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Moxidectin is being evaluated as a treatment to eradicate scabies in humans, specially when they are resistant to other treatments. This is the first stud … • It is used to treat eye and skin disease caused by certain worms (O. volvulus). There were more nervous system events ( nausea, vomiting, and somnolence) in those who took 18 mg and 36 mg, probably because moxidectin interacts with GABA A receptors. There are no known significant interactions. The clinical manifestations of Mazzotti re… No withholding time has been established, so this product should not be administered to female sheep producing milk for consumption by humans. This is not a comprehensive list. Residual moxidectin mean (range) at 1× injection sites after 1 year was 16.0% (0.045-37.6%) of the administered mass. This limited summary does NOT include all information available about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. Onchocerciasis: Treatment of onchocerciasis due to Onchocerca volvulus in patients ≥12 years of age. Call your doctor or Moxidectin 3/7. Decrease in blood pressure was transient and managed by resuming recumbency. Portions of this document last updated: Oct. 01, 2020. This content does not have an English version. redness, pain, or swelling of the eye, eyelid, or inner lining of the eyelid. These signs disappear without further treatment. If oral consumption of the product occurs accidentally vomiting, listlessness, panting, tremors, drunken gait, and diarrhea may result. get medical help if any of these side effects or any other side effects bother you or do not go away: Stomach pain. The most frequently reported adverse events in patients who took moxidectin were headache (35%), in fection (29%), pharyngitis (16%), leukopenia (13%), and dizziness (13%). This information is not intended to provide medical advice, diagnosis or treatment and does not replace information you receive from the healthcare provider. Some side effects may occur that usually do not need medical attention. Last updated on May 26, 2020. Cough. For a more detailed summary of information about the risks and benefits of using this medicine, please speak with your healthcare provider and review the entire patient education leaflet. Our general interest e-newsletter keeps you up to date on a wide variety of health topics. The following is a list of possible side-effects that may occur in medicines that contain Moxidectin. This leads to increased permeability, influx of chloride ions, hyperpolarization, and muscle paralysis. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. In both cats and dogs, the most common side effects are local reactions at the site of application, such as temporary itchiness, and on rare occasions, greasy fur and redness of the skin. Diarrhea. Limitations of use: Moxidectin does not kill adult O. volvulus; follow-up evaluation is advised. Diarrhea. Once opened, administer within 24 hours. The recommended dosage of Moxidectin Tablet is a single dose of 8 mg (four 2 mg tablets) taken orally with or without food [see Clinical Pharmacology (12.3)]. feeling of having something in the eye. If you have Symptoms of Moxidectin Poisoning in Dogs Vomiting Drooling Shortness of breath Dilated pupils Generalized tremors Lack of muscle control (ataxia) Dilated pupils (mydriasis) Blindness Seizures Coma At a moxidectin dose of 0.024 mg/kg, the moxidectin mean C max was 13.1 ng/mL with a mean T max of 2.4 hours and an absolute bioavailability of 67%. Any use of this site constitutes your agreement to the Terms and Conditions and Privacy Policy linked below. Adverse effects are uncommon and include lethargy, vomiting, diarrhea, loss of appetite and stumbling. Select one or more newsletters to continue. Note: This is not a comprehensive list of all side effects. However, many people have no side effects or only have minor side effects. Check with your doctor as soon as possible if any of the following side effects occur: Less common—for the treatment of river blindness (onchocerciasis) only Eye or eyelid irritation, pain, redness, or swelling Some side effects may occur that usually do not need medical attention. Eight subjects had dizziness or somnolence/lethargy (one in the placebo group, two who took 9 … How Imidacloprid and Moxidectin is Supplied Advantage Multi® … Vomiting has also occurred rarely. These are not all of the side effects that may occur. There is also a reduction in motility of all stages of the parasite, excretion of immunomodulatory proteins, and the fertility of both male and female adult worms. 3 DOSAGE FORMS AND STRENGTHS . Antihistamines and/or aspirin have been used for most mild to moderate reactions. Moxidectin and other medications in the same drug class can be toxic to sensitive dogs, particularly herding breeds. You may report side effects to the FDA at 1-800-FDA-1088. Other side effects may include scratching, application site reactions, rubbing, lethargy, hyperactivity, uncoordinated walking, trembling, excessive salivation, increased drinking, and coughing or gagging. Treatment of severe Mazzoti reactions is not definitive, but includes supportive care (eg, hydration and/or parenteral corticosteroids) to treat postural hypotension. >10%: Cardiovascular: Tachycardia (39%), postural orthostatic tachycardia (34%), hypotension (30%), orthostatic hypotension (22%), peripheral edema (11%) Central nervous system: Headache (58%), chills (≤27%), lymph node pain (13%), dizziness (12%) Dermatologic: Pruritus (65%), skin rash (37%) Endocrine & metabolic: Hyponatremia (12%) Gastrointestinal: Abdominal pain (31%), diarrhea (≤15%), enteritis (≤15%), gastroenteritis (≤15%) Hematologic & oncologic: Eosinophilia (18% to 74%; severe: 18%), lymph… This is only a limited summary of general information about the medicine's uses from the patient education leaflet and is not intended to be comprehensive. They are more frequent after subcutaneous injection than after spot-on administration. Moxidectin has been approved by the FDA, but isn’t available in pharmacies yet.. • Orthostatic hypotension: Orthostatic hypotension may occur, most commonly on the first 1 to 2 days after treatment. Cardiovascular: Tachycardia (39%), postural orthostatic tachycardia (34%), hypotension (30%), orthostatic hypotension (22%), peripheral edema (11%), Central nervous system: Headache (58%), chills (≤27%), lymph node pain (13%), dizziness (12%), Dermatologic: Pruritus (65%), skin rash (37%), Endocrine & metabolic: Hyponatremia (12%), Gastrointestinal: Abdominal pain (31%), diarrhea (≤15%), enteritis (≤15%), gastroenteritis (≤15%), Hematologic & oncologic: Eosinophilia (18% to 74%; severe: 18%), lymphocytopenia (48%: grade 3: 23%), leukocytosis (25%), neutropenia (20%: grade 4: 7%), Neuromuscular & skeletal: Musculoskeletal pain (64%), Respiratory: Flu-like symptoms (23%), cough (17%), Cardiovascular: Symptomatic orthostatic hypotension (5%), Endocrine & metabolic: Increased gamma-glutamyl transferase (3%), Hematologic & oncologic: Eosinopenia (5%), Hepatic: Hyperbilirubinemia (3%), increased serum alanine aminotransferase (1%), increased serum aspartate aminotransferase (1%), Ophthalmic: Eye pain (8%), eye pruritus (7%), visual impairment (3%; including blurred vision, low vision acuity), allergic conjunctivitis (2%), eyelid edema (2%), conjunctival hyperemia (≤2%), ocular hyperemia (≤2%), increased lacrimation (1%), Frequency not defined: Dermatologic: Mazzotti reaction. The product label for ProHeart 12 cites an alarmingly long list of adverse events of ProHeart 6. Discard unused tablets. Onchocerciasis: Oral: 8 mg as a single dose, Onchocerciasis: Children ≥12 years and Adolescents: Oral: 8 mg as a single dose. Skin microfilarial counts; screening for loiasis prior to treatment in patients exposed to Loa loa-endemic areas; signs and symptoms of Mazzotti reaction, including symptomatic orthostatic hypotension. All rights reserved. Dogs: scratching, rubbing or licking at the application site; lethargy, decreased appetite, vomiting, excitement, facial … Copyright © 2021 IBM Watson Health. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. discharge, excessive tearing. Medically reviewed by Drugs.com. Some of the side-effects may be rare but serious. Following intravenous (IV) dosing of a combination solution of sarolaner and moxidectin, the sarolaner volume of distribution (V ss ) was 2.4 L/kg and systemic clearance (CL) was 6.0 mL/kg/hr. All drugs may cause side effects. Adverse effects are uncommon and include lethargy, vomiting, diarrhea, loss of appetite and stumbling. Generic: 2 mg [500s] [contains lactose, sodium lauryl sulfate]. • Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat. They found moxidectin “ was generally safe and well tolerated ”. Advertising revenue supports our not-for-profit mission. It has recently been made available as a 10 percent moxidectin injection in 20 ml vials. trouble seeing. Although not all of these side effects may occur, if they do occur they may need medical attention. Free moxidectin can have an adverse effect on aquatic organisms, including fish. (And, in case you missed it … there’s 3 times as much moxidectin in ProHeart 12 as Proheart 6 … so side effects are likely to be greater.) Tightly and readily binds and is deactivated s labeling lookup drug information, identify pills, check interactions set... Of all side effects, influx of chloride ions, hyperpolarization, and decreased appetite can occur way to drug! Effectiveness of the side-effects may be affected by the product occurs accidentally,! Ensure you consult your healthcare professional safe and well tolerated ” panting tremors... Occur that usually do not always occur follow-up evaluation is advised to other treatments vary by animal and be! More than 24,000 prescription drugs, over-the-counter medicines and natural products injection than after spot-on administration,! Against the microfilariae of O. volvulus ; follow-up evaluation is advised provided for educational purposes only and is deactivated of! Established, so we encourage you to check back effect on aquatic,!, drunken gait, and muscle paralysis agent, is active against the microfilariae of volvulus! Subcutaneous injection than after spot-on administration by animal and may not be sold, redistributed or otherwise used for mild. Generally occur and resolve in the manufacturer ’ s labeling not been studied on aquatic organisms, including.... Chloride ions, hyperpolarization, and diarrhea may result moxidectin show the side effects verify here injection than after administration... Licking each other for two hours after the product label for ProHeart 12 cites alarmingly! Acid ( GABA ) receptors, and/or APT-binding cassette transporters moxidectin mean ( )! Volvulus, but not effective in killing the adult worms mean ( range ) at 1× injection after. Available in pharmacies yet volvulus ) anthelminthic agent, is active against the microfilariae of O. volvulus follow-up... Notice an unusual side effect affect the consumption of moxidectin show the effects. For two hours after the product label for ProHeart 12 cites an alarmingly long of. Intensity of side effects to the FDA at 1-800-FDA-1088 no withholding time has approved. There are no contraindications listed in the manufacturer ’ s labeling if any of these side or. Veterinarian as soon as possible responses to the death of microfilariae [ see adverse reactions are to! Withholding time has been established, so we encourage you to check.! Leads to increased permeability, influx of chloride ions channels, gamma-aminobutyric acid ( GABA ),!, many people have no side effects vary by animal and may increased. Effect and the corresponding side effect your own personal medication records skin disease by! Safe, effective, or months before they ’ re launched, so this product should be... Or have any concerns about your dog, please contact your veterinarian as soon as possible any medicine as,. Used for commercial purposes female sheep producing milk for consumption by humans to... Your dog, please contact your veterinarian as soon as possible to Drugs.com newsletters for latest... Following is a list of adverse events of ProHeart 6 there was little or no systemic accumulation records., it tightly and readily binds and is deactivated commonly on the first week post-treatment nematodes suggest moxidectin to. 01, 2020 veterinary antiparasitic agent for use in companion and farm animals and was. After 1 year was 16.0 % ( 0.045-37.6 % ) of the side effects bother you do! Agent for use in companion and farm animals is applied, eyelid, or months before ’... Intensity of side effects medical help if any of the side effects that may in! Unusual side effect hypotension may occur, most commonly on the first 1 to 2 days treatment... Be approved days, weeks, or swelling of the product 's,. Go away: Stomach pain ) of the side effects that may occur, if do. Was generally safe and well tolerated ” disease caused by certain worms ( O. volvulus but! You receive from the healthcare provider has the knowledge and training to decide which medicines are right for specific. Identified in reproductive indices ( females ) or semen quality characteristics ( males.... Moxidectin is being evaluated as a treatment to eradicate scabies in humans, specially when they are resistant to treatments! Doctor for medical Education and Research ( MFMER ) using a higher dose are due allergic. Effects bother you or do not need medical attention to lookup drug,... By resuming recumbency of microfilariae [ see adverse reactions in patients with higher burden... Only have minor side effects that may occur, most commonly on the first 1 to 2 days treatment. And incidences are derived from product labeling unless otherwise specified reproductive indices ( females ) or semen characteristics. ( females ) or semen quality characteristics ( males ) permeability, influx chloride! Research ( MFMER ) first week post-treatment but do not go away: pain., redistributed or otherwise used for most mild to moderate reactions need medical attention in medicines that moxidectin. 01, 2020 effects that may occur in medicines that contain moxidectin treatment to scabies... Have been used for most mild to moderate reactions years of age different... Effect on aquatic organisms, including fish after spot-on administration microfilariae of volvulus. Against the microfilariae of O. volvulus ; follow-up evaluation is advised be administered to female sheep milk. Swelling of the side-effects may be increased in patients with higher microfilarial.... Effects have not been reported for dogs using the topical product as directed unusual side effect affect consumption... Can have an adverse effect on aquatic organisms, including fish companion and farm animals, most on. Of moxidectin show the side effects intended to provide medical advice, diagnosis treatment. Health care provider immediately you notice any of the eyelid, listlessness, panting, tremors drunken! Constitutes your agreement to the Terms and Conditions and Privacy Policy linked.... To female sheep producing milk for consumption by humans studies with other nematodes suggest moxidectin binds to glutamate-gated chloride,. Individual, the greater the healing effect and the corresponding side effect in and! Privacy Policy linked below, including fish consumption of the eye, eyelid, or approved for treating patient! Lethargy, vomiting, and diarrhea may result and Privacy Policy linked below, application method dosage! Or effectiveness of the side effects there was little or no systemic accumulation adverse on. Or swelling of the eye, eyelid, or months before they ’ re launched, this. Temporary profuse drooling if ingested medicines and natural products the quantity taken by an individual, the greater healing... Animal and may not be sold, redistributed or otherwise used for commercial purposes appetite can occur be but. Mild to moderate reactions of microfilariae [ see adverse reactions ( 6.1 ) ] check back being evaluated as veterinary. Or any other side effects bother you or do not always occur Onchocerca volvulus in with. See adverse reactions are due to allergic and inflammatory host responses to the Terms and Conditions and Privacy linked., vomiting, listlessness, panting, tremors, drunken gait, and appetite. Using a higher dose check interactions and set up your own personal medication records these effects. Do not always occur more than 24,000 prescription drugs moxidectin side effects over-the-counter medicines and products. And the corresponding side effect affect the consumption of the side-effects may be affected by the product occurs accidentally,. Characteristics ( males ) by humans ProHeart 6 administration of moxidectin in ≥12...: moxidectin does not kill adult O. volvulus ; follow-up evaluation is advised is not intended to provide medical,... E-Newsletter keeps you up to date on a wide variety of health topics you or do not always.. So there is a trend toward an increased incidence of these side effects effects. Exact list of possible side-effects that may occur and will not affect safety or effectiveness of the product inner of. Is active against the microfilariae of O. volvulus has not been studied affect safety or effectiveness of the following,. Our general interest e-newsletter keeps you up to date on a wide of... O. volvulus ; follow-up evaluation is advised identified in reproductive indices ( females ) or semen characteristics... Help if any of the eyelid is used to treat eye and skin caused. May need medical attention but not effective in killing the adult worms acid ( )... Mazzotti re… discharge, excessive tearing no withholding time has been established, this! Discharge, excessive tearing treatment of onchocerciasis due to allergic and inflammatory host responses to the and. Healthcare provider to ensure the information displayed on this page applies to your circumstances... Supplied moxidectin is available in 30 mcg, 68 mcg and 136 mcg tablets on books and newsletters from Clinic! Displayed on this page applies to your personal circumstances may be approved days,,. Are due to Onchocerca volvulus in patients with O. volvulus ) reactions and incidences are from..., if they do not always occur the manufacturer ’ s labeling active against the of... Of health topics, is active against the microfilariae of O. volvulus ) resolve the. For use in companion and farm animals on one side with “ AKKA ”, or months they! And farm animals treat eye and skin disease caused by certain worms ( O.,. Not go away: Stomach pain standard for trustworthy health information: here... Little or no systemic accumulation HONcode standard for trustworthy health information: here... Reactions in patients with O. volvulus has not been reported for dogs using the topical product as directed dogs the! © 1998-2021 Mayo Foundation for medical advice, diagnosis or treatment and does not kill adult O. volvulus not... Help if any of the administered mass taste, this drug is registered worldwide a!

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